A.P. Martinich's interpretation that in Leviathan Thomas Hobbes believed that the laws of nature are the commands of God and that he did not rely on the Bible to prove this has been criticized by Greg Forster in this journal (2003). Forster uses these criticisms to develop his own view that Hobbes was insincere when he professed religious beliefs. We argue that Forster misrepresents Martinich's view, is mistaken about what evidence is relevant to interpreting whether Hobbes was sincere or not, (...) and is mistaken about some of Hobbes's central doctrines. Forster's criticisms are worth discussing at length for at least three reasons. He takes the debate about Hobbes's sincerity to a new level of sophistication; his misinterpretations of Hobbes may become accepted as correct; and his criticisms raise issues about the proper method of interpreting historical texts. (shrink)

Objectives: Medical decision support and other intelligent applications in the life sciences depend on increasing amounts of digital information. Knowledge bases as well as formal ontologies are being used to organize biomedical knowledge and data. However, these two kinds of artefacts are not always clearly distinguished. Whereas the popular RDF(S) standard provides an intuitive triple-based representation, it is semantically weak. Description logics based ontology languages like OWL-DL carry a clear-cut semantics, but they are computationally expensive, and they are often misinterpreted (...) to encode all kinds of statements, including those which are not ontological. Method: We distinguish four kinds of statements needed to comprehensively represent domain knowledge: universal statements, terminological statements, statements about particulars and contingent statements. We argue that the task of formal ontologies is solely to represent universal statements, while the non-ontological kinds of statements can nevertheless be connected with ontological representations. To illustrate these four types of representations, we use a running example from parasitology. Results: We finally formulate recommendations for semantically adequate ontologies that can efficiently be used as a stable framework for more context-dependent biomedical knowledge representation and reasoning applications like clinical decision support systems. (shrink)

Background Informed consent is an integral component of good medical practice. Many researchers have investigated measures to improve the quality of informed consent, but it is not clear which techniques work best and why. To address this problem, we propose developing a core outcome set to evaluate interventions designed to improve the consent process for surgery in adult patients with capacity. Part of this process involves reviewing existing research that has reported what is important to patients and doctors in the (...) informed consent process. Methods This qualitative synthesis comprises four phases: identification of published papers and determining their relevance; appraisal of the quality of the papers; identification and summary of the key findings from each paper while determining the definitiveness of each finding against the primary data; comparison of key themes between papers such that findings are linked across studies. Results Searches of bibliographic databases returned 11,073 titles. Of these, 16 studies met the inclusion criteria. Studies were published between 1996 and 2016 and included a total of 367 patients and 74 health care providers. Thirteen studies collected data using in-depth interviews and constant comparison was the most common means of qualitative analysis. A total of 94 findings were extracted from the primary papers and divided into 17 categories and ultimately 6 synthesised findings related to: patient characteristics, knowledge, communication, the model patient, trust and decision making. Conclusions This qualitative meta-aggregation is the first to examine the issue of informed consent for surgery. It has revealed several outcomes deemed important to capture by patients and clinicians when evaluating the quality of a consent process. Some of these outcomes have not been examined previously in research comparing methods for informed consent. This review is an important step in the development of a COS to evaluate interventions designed to improve the consent process for surgery. Registration The study protocol was registered on the international prospective register for systematic reviews. (shrink)

Junior researchers can be abused and bullied by unscrupulous senior collaborators. This article describes the profile of a type of serial abuser, the White Bull, who uses his academic seniority to distort authorship credit and who disguises his parasitism with carefully premeditated deception. Further research into the personality traits of such perpetrators is warranted.

A new formulation involving fulfillment of all the Kolmogorov axioms is suggested for acomplete probability theory. This proves to be not a purely mathematical discipline. Probability theory deals with abstract objects—images of various classes of concrete objects—whereas experimental statistics deals with concrete objects alone. Both have to be taken into account. Quantum physics and classical statistical physics prove to be different aspects ofone probabilistic physics. The connection of quantum mechanics with classical statistical mechanics is examined and the origin of the (...) Schrödinger equation is elucidated. Attention is given to the true meaning of the wave-corpuscle duality, and the incompleteness of nonrelativistic quantum mechanics is explained. (shrink)

Jean Philiponus s'est toujours opposé à la notion nestorienne des anges servant les hommes à la place de Dieu. Jean Philiponus s'inscrit dans le courant égyptien critique de la fin du VIe siècle de certains récits apocryphes des anges dans l'univers primitif. L'argumentation de Philoponus est anti-dyophysite. Il s'attache à démontrer que l'univers que nous percevons est peuplé d'entités non corporelles puissantes, au service de Dieu et dont le rôle est de faire passer des messages aux êtres humains. Ces entités (...) ont été créées par le Dieu trinitaire avant l'acte divin de création. (shrink)

Some problems relating to the probabilistic description of a free particle and of a charged particle moving in an electromagnetic field are discussed. A critical analysis of the Klein-Gordon equation and of the Dirac equation is given. It is also shown that there is no connection between commutativity of operators for physical quantities and the existence of their joint probability. It is demonstrated that the Heisenberg uncertainty relation is not universal and explained why this is so. A universal uncertainty relation (...) for canonically conjugate coordinates and momenta is suggested. (shrink)

My purpose in what follows is not so much to defend the basic principle of utilitarianism as to indicate the form of it which seems most promising as a basic moral and political position. I shall take the principle of utility as offering a criterion for two different sorts of evaluation: first, the merits of acts of government, social policies, and social institutions, and secondly, the ultimate moral evaluation of the actions of individuals. I do not take it as implying (...) that the individual should live his life on the basis of constant evaluations of this sort. For there are different levels of decision making each with its appropriate criteria. For example, we each inevitably make many of our decisions from the point of view of our own personal self-fulfilment and this cannot regularly take a directly utilitarian form, nor should the utilitarian want it to do so. His claim is at most that we should sometimes review our life from the point of view of a kind of impersonal moral truth of a universalistic utilitarian character. (shrink)

General regularities related toLagrangian andHamiltonian equations are revealed. Probability distributions for functions ofHamiltonian random variables are considered. It is shown that all probability distributions of this kind are fully determined by the probability distributions for the random variables satisfying the corresponding Lagrangian equations. Some formulas related tocanonically conjugate operators are given. The similarity of these formulas to those related to Hamiltonian random variables is demonstrated. The “quantum approach” to the treatment of Hamiltonian random variables is discussed, and the origin of (...) some peculiarities related to this approach is elucidated; it is explained, in particular, why it is impossible to form the joint probability density for canonically conjugate random variables when using this approach. The peculiarities revealed prove to be common for any objects possessing Hamiltonian random variables, irrespective of the nature of the objects, and coincide, therefore, with those in quantum mechanics. The existence of joint probability distributions for canonically conjugate random variables in the general case is demonstrated through the calculation of the corresponding joint mathematical expectations in an illustrative example. This proves, in particular, that joint probability distributions for canonically conjugate coordinates and momenta exist indeed in the case of mechanical microsystems. The results obtained prove once again that the pecularities of quantum mechanics are not related to the specificity of the measurements of physical quantities for microsystems. (shrink)